Vuk Savkovic

Publikationen

Ausgewählte Publikationen und Referenzen

Buchkapitel

Savkovic V., Schneider M., Li H., Simon JC., Ziemer M., Lethaus B. (2021) Generation of Epidermal

Equivalents from Hair Follicle Melanocytes, Keratinocytes, and Dermal Fibroblasts. In: Stock P., Christ

B. (eds) In Vitro Models for Stem Cell Therapy. Methods in Molecular Biology, vol 2269. Humana,

New York, NY. https://doi.org/10.1007/978-1-0716-1225-5_13

U.Anderer, V.Savkovic 2015 Zelltherapien in der Regenerativen Medizin,. Book chapter in Zelluläre

Diagnostik und Therapie, U.Sack. 291-327. De Gruyter

Marie Schneider, Christina Dieckmann, Katrin Rabe, Jan--Christoph Simon, Vuk Savkovic.

Differentiating the stem cell pool of human hair follicle outer root sheath into functional

melanocytes. Book chapter in Methods Mol Biol. 2014;1210:203-27. Humana Press, Springer Link

Laura Baumgartner , Vuk Savkovic , Susanne Trettner , Colette Martin and Nicole I. zur Nieden. Stem

Cells and Their Use in Skeletal Tissue Repair, book chapter in ‚Stem Cells and Regenerative Medicine‘,

Stem Cell Biology and Regenerative Medicine, 2011, Part 1, 103-124, Humana Press, Springer Link

DOI: 10.1007/978-1-60761-860-7_7, ISBN 978-1-60761-859-1, e-ISBN 978-1-60671-860-7

Beatrice Kuske, Vuk Savkovic and Nicole I. zur Nieden, Improved Media compositions for the

Differentiation of Embryonic Stem Cells into Osteoblasts and Chondrocytes. Embryonic Stem Cell

Therapy for Osteo-Degenerative Diseases: Methods and Protocols, Methods in Molecular Biology,

Vol 690, 195-215 DOI: 10.1007/978-1-60761-962-8_14

Fachzeitschriften

Savkovic, V, Lethaus, B. Mesenchymale Stammzellen: Quellen und therapeutisches Potenzial. Trillium

Diagnostik, TD 2/2022 Immunologie. DOI: https://doi.org/10.47184/td.2022.02.02

Peer-Reviewed 2019-2025

Li, H.; Wilhelm, M.; Baumbach, C.M.; Hacker, M.C.; Szardenings, M.; Rischka, K.; Koenig, A.; Schulz-

Kornas, E.; Fuchs, F.; Simon, J.C.; Lethaus, B, Savkovic, V. Laccase-Treated Polystyrene Surfaces with Caffeic Acid, Dopamine, and L-3,4-Dihydroxyphenylalanine Substrates Facilitate the Proliferation of Melanocytes and Embryonal Carcinoma Cells NTERA-2. Int. J. Mol. Sci. 2024, 25, 5927.

Mićanović, D.; Stanisavljević, S.; Li, H.; Koprivica, I.; Jonić, N.; Stojanović, I.; Savković, V.; Saksida, T.

Mesenchymal Stem Cells from Mouse Hair Follicles Inhibit the Development of Type 1 Diabetes. Int.

J. Mol. Sci. 2024, 25, 5974.

Li, H., Xiong, S., Masieri, F.F. , Savkovic, V. et al. Mesenchymal Stem Cells Isolated from Equine Hair Follicles Using a Method of Air-Liquid Interface. Stem Cell Rev and Rep (2023). https://doi.org/10.1007/s12015-023-10619-w

Li H, Ziemer M, Stojanovic I, Saksida T, Maksimovic-Ivanic D, Mijatovic S, Djmura G, Gajic D, Koprivica

I, Krajnovic T, Draca D, Simon JC, Lethaus B, Savkovic V. Mesenchymal Stem Cells From Mouse Hair

Follicles Reduce Hypertrophic Scarring in a Murine Wound Healing Model. Stem Cell Rev Rep. 2022

Jan 26. doi: 10.1007/s12015-021-10288-

Li S, Wang Y, Sun R, Franceschi D, Pan H, Wei C, Ogbuehi AC, Lethaus B, Savkovic V, Gaus S, Zimmerer

R, Ziebolz D, Schmalz G, Jiang X. Single-Cell Transcriptome Analysis Reveals Different Immune

Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma. J Immunol

Res. 2022 Sep 16;2022:2079389. doi: 10.1155/2022/2079389. PMID: 36157879; PMCID:

PMC9507777.

Schneider M, Ziemer M, Lethaus B, Simon JC, Savkovic V. Generation of Pigmented Skin Grafts from

Human Hair Follicles and Dermal Fibroblasts. Tissue Eng Part A. 2021 Oct;27(19-20):1333-1342. doi:

10.1089/ten.TEA.2020.0284. PMID: 33573455.

Gaus S, Li H, Li S, Wang Q, Kottek T, Hahnel S, Liu X, Deng Y, Ziebolz D, Haak R, Schmalz G, Liu L,

Savkovic V, Lethaus B. Shared Genetic and Epigenetic Mechanisms between the Osteogenic

Differentiation of Dental Pulp Stem Cells and Bone Marrow Stem Cells. Biomed Res Int. 2021 Feb

5;2021:6697810. doi: 10.1155/2021/6697810. PMID: 33628811; PMCID: PMC7884974.

Savkovic V, Li H, Obradovic D, Masieri FF, Bartella AK, Zimmerer R, Simon JC, Etz C, Lethaus B. The

Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath. J Clin Med.

2021 Feb 26;10(5):911. doi: 10.3390/jcm10050911. PMID: 33652691; PMCID: PMC7956349.

Li H, Nawaz HA, Masieri FF, Vogel S, Hempel U, Bartella AK, Zimmerer R, Simon JC, Schulz-Siegmund M, Hacker M, Lethaus B, Savković V. Osteogenic Potential of Mesenchymal Stem Cells from Adipose Tissue, Bone Marrow and Hair Follicle Outer Root Sheath in a 3D Crosslinked Gelatin-Based Hydrogel. Int. J. Mol. Sci. 2021, 22, 5404. https://doi.org/10.3390/ijms 22105404

Hanluo Li, Christina Baumbach, Marie Schneider, Katrin Rabe, Tina Kottek, Jan-Christoph Simon, Vuk

Savkovic, Bernd Lethaus. Functional melanocytes obtained from rabbit hair follicle outer root sheath.

Research Square 2021, pre-publish

Li, H.; Michler, J.K.; Bartella, A.; Sander, A.K.; Gaus, S.; Hahnel, S.; Zimmerer, R.; Simon, J.-C.; Savkovic,

V.; Lethaus, B. Culturing of Melanocytes from the Equine Hair Follicle Outer Root Sheath. Processes

2021, 9, 177.

Li, H.; Masieri, F.F.; Schneider, M.; Bartella, A.; Gaus, S.; Hahnel, S.; Zimmerer, R.; Sack, U.;

Maksimovic-Ivanic, D.; Mijatovic, S.; Simon, J.-C.; Lethaus, B.; Savkovic, V. The Middle Part of the

Plucked Hair Follicle Outer Root Sheath Is Identified as an Area Rich in Lineage-Specific Stem Cell

Markers. Biomolecules 2021, 11, 154. https://doi.org/10.3390/biom11020154

Wanchen Ning, Yihong Ma, Simin Li, Xin Wang, Hongying Pan, Chenxuan Wei, Shaochuan Zhang,

Dongying Bai, Xiangqiong Liu, Yupei Deng, Aneesha Acharya, George Pelekos, Vuk Savkovic, Hanluo

Li, Sebastian Gaus, Rainer Haak, Gerhard Schmalz, Dirk Ziebolz, Yanbo Ma, Yuzhen Xu, "Shared

Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic

Alterations of Peripheral Blood Monocytes", Computational and Mathematical Methods in Medicine,

vol. 2021, Article ID 1498431, 28 pages, 2021. https://doi.org/10.1155/2021/1498431

Li H, Masieri FF, Schneider M, Kottek T, Hahnel S, Yamauchi K, Obradović D, Seon JK, Yun SJ, Ferrer

RA, Franz S, Simon JC, Lethaus B, Savković V. Autologous, Non-Invasively Available Mesenchymal

Stem Cells from the Outer Root Sheath of Hair Follicle Are Obtainable by Migration from Plucked Hair

Follicles and Expandable in Scalable Amounts. Cells. 2020 Sep 10;9(9):2069. doi:

10.3390/cells9092069. PMID: 32927740; PMCID: PMC7564264.

Li H, Sack U, Li S, Simon JC, Lethaus B, Savkovic V. Next Generation Sequencing-based mRNA

sequencing of human adipose mesenchymal stem cells. Gene Expression Omnibus Accession:

GSE159137 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159137

Li H, Sack U, Li S, Simon JC, Lethaus B, Savkovic V. Next Generation Sequencing-based on mRNA

sequencing of human adipose mesenchymal stem cells submitted to osteogenic differentiation. Gene

Expression Omnibus Accession: GSE159138

Li H, Sack U, Li S, Simon JC, Lethaus B, Savkovic V. Next Generation Sequencing based mRNA

sequencing of human mesenchymal stem cells from hair follicle outer root sheath. Gene Expression

Omnibus Accession: GSE159139

Li H, Sack U, Li S, Simon JC, Lethaus B, Savkovic V. Next Generation Sequencing based mRNA

sequencing of osteogenic differentiation of human mesenchymal stem cells from hair follicle outer

root sheath (MSCORS). Gene Expression Omnibus Accession: GSE159140

Wang X, Li S, Ma Y, Xu Y, Ogbuehi AC, Hu X, Acharya A, Haak R, Ziebolz D, Schmalz G, Li H, Gaus S,

Lethaus B, Savkovic V, Su Z. Identification of miRNAs as the Crosstalk in the Interaction between

Neural Stem/Progenitor Cells and Endothelial Cells. Dis Markers. 2020 Dec 11;2020:6630659. doi:

10.1155/2020/6630659. PMID: 33381243; PMCID: PMC7758130.

Obradovic D, Loncar G, Radenovic S, Tahirovic E, Heidecke H, Schulze-Forster K, Muller D, Busjahn A,

Buttner P, Veskovic J, Zdravkovic M, Li H, Li S, Savkovic V, Pieske B, Dungen HD, Dechend R. Soluble

(pro)renin receptor in elderly chronic heart failure patients. Front Biosci (Landmark Ed). 2020 Jun

1;25:1839-1853.

Wang X, Li S, Ma Y, Xu Y, Ogbuehi AC, Hu X, Acharya A, Haak R, Ziebolz D, Schmalz G, Li H, Gaus S,

Lethaus B, Savkovic V, Su Z. Identification of miRNAs as the Crosstalk in the Interaction between

Neural Stem/Progenitor Cells and Endothelial Cells. Dis Markers. 2020 Dec 11;2020:6630659. doi:

10.1155/2020/6630659. PMID: 33381243; PMCID: PMC7758130.

Schneider M, Rother S, Möller S, Schnabelrauch M, Scharnweber D, Simon JC, Hintze V, Savkovic V.

Sulfated hyaluronan-containing artificial extracellular matrices promote proliferation of keratinocytes

and melanotic phenotype of melanocytes from the outer root sheath of hair follicles. J Biomed Mater

Res A. 2019 Aug;107(8):1640-1653. doi: 10.1002/jbm.a.36680. Epub 2019 Apr 23. PMID: 30916871.

Jiaming Wang, Xiaoxi Xi, Wei Shang, Aneesha Acharya, Simin Li, Vuk Savkovic, Hanluo Li, Rainer Haak,

Jana Schmidt, Xiangqiong Liu, Yupei Deng, Hongying Pan, Danilo Obradovic, Gerhard Schmalz, Dirk

Ziebolz, Xianda Hu, The molecular differences between human papillomavirus-positive and -negative

oropharyngeal squamous cell carcinoma: A bioinformatics study, American Journal of

Otolaryngology, Volume 40, Issue 4, 2019, Pages 547-55

Wang J, Xi X, Shang W, Acharya A, Li S, Savkovic V, Li H, Haak R, Schmidt J, Liu X, Deng Y, Pan H, Obradovic D, Schmalz G, Ziebolz D, Hu X. The molecular differences between human papillomavirus-

positive and -negative oropharyngeal squamous cell carcinoma: A bioinformatics study. Am J Otolaryngol. 2019 Jul-Aug;40(4):547-554. doi: 10.1016/j.amjoto.2019.04.015. Epub 2019 Apr 23.

Y Ma, S Li, X Wang, V Savkovic, H Li, S Zhang, S Gaus, R Haak, D.Ziebolz, G.Schmalz. Shared Molecular

Mechanisms Between Atherosclerosis And Chronic Periodontitis Revealed By Transcriptomic

Analysis. International Journal Of Stroke 15 (1_ Suppl), 628-628

Lebenslauf

Seit 02/2025

Wissenschaftlicher Mitarbeiter im KAT-Projekt „Begleitforschung Schlüsseltechnologien“

Prorektorat für Forschung, Wissenstransfer und Existenzgründung, 

Hochschule Merseburg

Seit 2023

Lehrbeauftragter Einführung in Toxikologie, Gentechnik, Umweltchemie

Hochschule Merseburg

Seit 2016

Gastprofessor

Suffolk University, Ipswich, Großbritannien

Seit 2023

Gastprofessor

Hubei Universität, China

07/2019-02/2025

Laborleiter/ Head Research

Klinik- und Poliklinik für Mund- Kiefer- und Gesicht Plastische

Chirurgie, Universitätsklinik Leipzig

03/2016-12/2018

Geschäftsführer Forschung und Translation

Sächsischer Inkubator für Klinische

Translation (SIKT), Universität Leipzig

10/2009-03/2016

Principal Investigator /Gruppenleiter (Haut)

Translationszentrum für Regenerative

Medizin (TRM), Universität Leipzig

10/2007-10/2009

Wissenschaftler

Fraunhofer Institut für Zelltherapie und Immunologie Leipzig

07/2005-10/2007

Wissenschaftlicher Mitarbeiter, Lehrassistent

Carl-Ludwig-Institut für Physiologie, Medizinische Fakultät, Universität Leipzig

07/2005

Promotion, Abschluss: Dr. rer. nat., Universität Leipzig

10/1996- 10/2000

Lehrassistent

Lehrstuhl Genetik und Evolution, Biologische Fakultät, Belgrad Universität, Belgrad, Jugoslawien

1997-2000

Gast Dozent

Petnica (YUG) Research Station